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Q. While running is good for my health, will it also make me lose muscle? Like anything in life, balance is key. If you overdo your running and don't allow for rest, nutrition and strength training then you will experience unhealthy weight loss with a fair share being muscle loss. Any runner who repeatedly experiences coughs and colds, general fatigue and loss of interest in life is suffering from over-training. Sadly, basis the common misperception that "more is better", many runners don't ...